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Pterostilbene

Also known as: Methylated resveratrol analog

Preliminary evidencePolyphenolNeeds evidence reviewModerate cautionHealthy Aging

Pterostilbene is a polyphenol structurally related to resveratrol and found in blueberries and some other plants. Its methylated structure is often discussed as giving it better absorption than resveratrol. It is explored in healthy-aging contexts, but human evidence is preliminary. Some research has raised questions about effects on blood lipids at higher doses, which is worth discussing with a qualified healthcare professional.

Not medical advice. SuppSafety and StackWise are informational only. Talk to a qualified healthcare professional before starting, stopping, or combining supplements.

Snapshot

Evidence levelPreliminary evidence
Caution levelModerate caution
Source reviewNeeds evidence review
Last reviewed

What this page can tell you: Commonly discussed timing, food notes, caution categories, and an honest note on how much source review this entry still needs.

What it cannot: Whether this is appropriate for you personally, or that it treats, prevents, or cures any condition. Informational only — discuss with a clinician or pharmacist.

🕒 Timing

When: With a meal

Food: With a meal containing fat

Fat-soluble compound; commonly taken with a meal containing fat.

💊 Common use range

50–125 mg

Higher doses used in some studies have prompted questions about lipid effects; no formal upper limit is established — verify and discuss with a professional.

Ranges are informational, not a recommended dose. Talk to a professional about what is right for you.

⚠️ Commonly noted interactions (supplements)

None listed.

Often about absorption or timing rather than danger — separating doses is common. This list is not exhaustive.

🧭 Caution level

Moderate caution
  • Evidence not fully source-reviewed yet

Caution level is an informational summary of commonly discussed caution categories and doses — not a safety rating, approval, or medical advice. Low caution does not mean safe for you.

🩺 Medication caution categories

None flagged here, but always review your full routine with a professional.

🏥 Surgery & procedure caution

Not a well-established surgical concern; share your full supplement list with your care team.

If you have a procedure scheduled, bring your full supplement list to your surgical and anesthesia team. Do not stop prescribed medication unless your clinician tells you to. Do not start or stop supplements based only on this app.

✅ Quality checklist

  • Prefer products with third-party testing or a certificate of analysis (COA).
  • Check the label for the exact form and the elemental or active amount per serving.

🧩 Commonly paired with

🔁 Alternatives

🗣️ Questions for a professional

  • Given the questions raised about lipids, is pterostilbene appropriate for me?

🔬 Evidence snapshot

Overall evidence level here is listed as "Preliminary evidence". A detailed, source-reviewed evidence summary has not been completed yet.

🧪 Forms & quality

Needs evidence review — no source-reviewed information yet. We only show dose and monitoring details after they have been checked against reputable sources.

See the supplement glossary for what form names like "L-", chelated, or standardized extract mean.

📏 Dose & monitoring

Needs evidence review — no source-reviewed information yet. We only show dose and monitoring details after they have been checked against reputable sources.

Evidence vs. burden: Not yet reviewed

😐 Commonly reported side effects

  • Limited human data; questions about lipid changes at higher doses have been raised in some research

Non-exhaustive and individual.

🔄 Cycling & breaks

No established cycling pattern.

📅 Daily use notes

Some research has raised questions about effects on lipids at higher doses; discuss with a professional, especially if you monitor cholesterol.

📋 Source review status

Needs evidence review

Placeholder — verify with MedlinePlus and available pterostilbene human trials, including the lipid discussions, before publishing.

Research backlog (queries to verify):

  • pterostilbene human trial healthy aging
  • pterostilbene LDL cholesterol dose effect study

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Not medical advice. SuppSafety and StackWise are informational research and tracking tools. They are not medical advice and do not diagnose, treat, cure, or prevent any condition. Supplement research is often limited or mixed, and individual needs vary. Always talk to a qualified healthcare professional before starting, stopping, or combining supplements — especially if you take medication, have a health condition, are pregnant or breastfeeding, or have a procedure scheduled.