SuppSafety is informational only and not medical advice. Read the disclaimer.

Resveratrol

Also known as: Trans-resveratrol, Polygonum cuspidatum extract

Mixed evidencePolyphenolNeeds evidence reviewHigh cautionHealthy AgingHeart & Circulation

Resveratrol is a polyphenol found in grapes, red wine, and certain plants, and it is widely discussed in healthy-aging and heart-wellness contexts. It is important to be honest here: results in human studies have generally been much weaker and more mixed than the striking effects seen in laboratory and animal research, partly because the body absorbs and processes it quickly. Interest remains high, but the human evidence does not match the hype.

Not medical advice. SuppSafety and StackWise are informational only. Talk to a qualified healthcare professional before starting, stopping, or combining supplements.

Snapshot

Evidence levelMixed evidence
Caution levelHigh caution
Source reviewNeeds evidence review
Last reviewed

What this page can tell you: Commonly discussed timing, food notes, caution categories, and an honest note on how much source review this entry still needs.

What it cannot: Whether this is appropriate for you personally, or that it treats, prevents, or cures any condition. Informational only — discuss with a clinician or pharmacist.

🕒 Timing

When: With a meal

Food: With a meal containing fat

Fat-soluble compound; commonly taken with a meal containing fat.

💊 Common use range

150–500 mg

Doses in studies vary widely; higher intakes have been linked to digestive upset — verify and follow product guidance.

Ranges are informational, not a recommended dose. Talk to a professional about what is right for you.

⚠️ Commonly noted interactions (supplements)

None listed.

Often about absorption or timing rather than danger — separating doses is common. This list is not exhaustive.

🧭 Caution level

High caution

Ask a clinician or pharmacist before use.

  • Bleeding / surgery caution category
  • Anticoagulant (blood thinner) interaction
  • Antiplatelet interaction
  • Evidence not fully source-reviewed yet

Caution level is an informational summary of commonly discussed caution categories and doses — not a safety rating, approval, or medical advice. Low caution does not mean safe for you.

🩺 Medication caution categories

  • Blood thinners (anticoagulants)
  • Antiplatelet medication

🏥 Surgery & procedure caution

Bleeding

Because it is sometimes discussed in relation to bleeding, talk to a qualified healthcare professional about your full supplement list well before any scheduled procedure.

If you have a procedure scheduled, bring your full supplement list to your surgical and anesthesia team. Do not stop prescribed medication unless your clinician tells you to. Do not start or stop supplements based only on this app.

✅ Quality checklist

  • Prefer products with third-party testing or a certificate of analysis (COA).
  • Check the label for the exact form and the elemental or active amount per serving.

🔁 Alternatives

🗣️ Questions for a professional

  • I take a blood thinner or antiplatelet medication — is resveratrol something to avoid?

🔬 Evidence snapshot

Overall evidence level here is listed as "Mixed evidence". A detailed, source-reviewed evidence summary has not been completed yet.

🧪 Forms & quality

Needs evidence review — no source-reviewed information yet. We only show dose and monitoring details after they have been checked against reputable sources.

See the supplement glossary for what form names like "L-", chelated, or standardized extract mean.

📏 Dose & monitoring

Needs evidence review — no source-reviewed information yet. We only show dose and monitoring details after they have been checked against reputable sources.

Evidence vs. burden: Not yet reviewed

😐 Commonly reported side effects

  • Digestive upset at higher doses

Non-exhaustive and individual.

🔄 Cycling & breaks

No established cycling pattern.

📅 Daily use notes

It is sometimes discussed as having blood-thinning potential, so it is worth flagging to a professional if you take blood thinners or antiplatelet medication.

📋 Source review status

Needs evidence review

Placeholder — verify with NIH ODS, MedlinePlus, and recent resveratrol human trial reviews before publishing.

Research backlog (queries to verify):

  • resveratrol human clinical trial outcomes versus preclinical
  • resveratrol bioavailability limitations
  • resveratrol bleeding blood thinner interaction

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Not medical advice. SuppSafety and StackWise are informational research and tracking tools. They are not medical advice and do not diagnose, treat, cure, or prevent any condition. Supplement research is often limited or mixed, and individual needs vary. Always talk to a qualified healthcare professional before starting, stopping, or combining supplements — especially if you take medication, have a health condition, are pregnant or breastfeeding, or have a procedure scheduled.