Resveratrol
Also known as: Trans-resveratrol, Polygonum cuspidatum extract
Resveratrol is a polyphenol found in grapes, red wine, and certain plants, and it is widely discussed in healthy-aging and heart-wellness contexts. It is important to be honest here: results in human studies have generally been much weaker and more mixed than the striking effects seen in laboratory and animal research, partly because the body absorbs and processes it quickly. Interest remains high, but the human evidence does not match the hype.
Snapshot
Evidence level is outcome-specific; a supplement can have stronger evidence for one use and limited evidence for another.
What this page can tell you: Commonly discussed timing, food notes, caution categories, and an honest note on how much source review this entry still needs.
What it cannot: Whether this is appropriate for you personally, or that it treats, prevents, or cures any condition. Informational only — discuss with a clinician or pharmacist.
🕒 Timing
When: With a meal
Food: With a meal containing fat
Fat-soluble compound; commonly taken with a meal containing fat.
💊 Common use range
150–500 mg
Doses in studies vary widely; higher intakes have been linked to digestive upset — verify and follow product guidance.
Ranges are informational, not a recommended dose. Talk to a professional about what is right for you.
⚠️ Commonly noted interactions (supplements)
None listed.
Often about absorption or timing rather than danger — separating doses is common. This list is not exhaustive.
🧭 Baseline caution
General caution for ordinary, common use — before accounting for your specific dose, medications, health history, or procedures.
No general caution factors flagged for ordinary use. See context alerts below for situations that may still apply to you.
Caution level is an informational summary of commonly discussed caution categories and doses — not a safety rating, approval, or medical advice. Low caution does not mean safe for you.
🔎 Context alerts to review
Context alerts may matter depending on your dose, medications, health history, or procedure plans — they do not mean the supplement is generally risky at ordinary use.
Surgery & bleeding
- Bleeding / surgery caution — mention before procedures and with blood thinners
Medications
- Anticoagulant (blood thinner) interaction
- Antiplatelet interaction
🩺 Medication caution categories
- Blood thinners (anticoagulants) — The concern is an additive effect on bleeding, or a change in how the anticoagulant works — worth raising with your prescriber, especially before procedures.
- Antiplatelet medication — Like blood thinners, the worry is added bleeding risk when combined — a prompt to check with a professional.
🏥 Surgery & procedure caution
Because it is sometimes discussed in relation to bleeding, talk to a qualified healthcare professional about your full supplement list well before any scheduled procedure.
If you have a procedure scheduled, bring your full supplement list to your surgical and anesthesia team. Do not stop prescribed medication unless your clinician tells you to. Do not start or stop supplements based only on this app.
✅ Quality checklist
- Prefer products with third-party testing or a certificate of analysis (COA).
- Check the label for the exact form and the elemental or active amount per serving.
🧩 Commonly paired with
🔁 Alternatives
🗣️ Questions for a professional
- I take a blood thinner or antiplatelet medication — is resveratrol something to avoid?
🔬 Evidence snapshot
Human evidence for resveratrol's healthy-aging and cardiovascular benefits is limited and inconsistent — clinical outcomes range from modestly favorable to null — and popular anti-aging claims far exceed what human studies support. It is generally well tolerated at typical doses (mild nausea/diarrhea at higher intakes), but its benefits in people remain unproven. NCCIH notes it may interact with anticoagulant/antiplatelet medicines.
🧪 Forms & quality
Needs evidence review — no source-reviewed information yet. We only show dose and monitoring details after they have been checked against reputable sources.
See the supplement glossary for what form names like "L-", chelated, or standardized extract mean.
📏 Dose & monitoring
Needs evidence review — no source-reviewed information yet. We only show dose and monitoring details after they have been checked against reputable sources.
Evidence vs. burden: Not yet reviewed
😐 Commonly reported side effects
- Digestive upset at higher doses
Non-exhaustive and individual.
🔄 Cycling & breaks
No established cycling pattern.
📅 Daily use notes
NCCIH notes resveratrol may interact with anticoagulant/antiplatelet medicines, so flag it to a professional if you take blood thinners. It may also have estrogen-like activity — worth discussing if you have an estrogen-sensitive condition.
📋 Source review status
Source-reviewed — last reviewed 2026-07-11
Reconciled 2026-07-11: NCCIH + a peer-reviewed review (PMC7143620). Human evidence limited/inconsistent; well tolerated with mild GI effects at higher doses; NCCIH-confirmed anticoagulant/antiplatelet interaction; possible estrogenic activity. No anti-aging/disease-prevention claims. CYP interactions remain unverified in humans (not asserted).
📚 References
- NCCIH — Type 2 Diabetes and Dietary Supplements (resveratrol safety)NCCIH — Resveratrol appears safe orally but may interact with anticoagulant/antiplatelet drugs and supplements; low-certainty evidence for benefit.
- Peer-reviewed review — resveratrol health effects & tolerabilityPubMed review — Clinical outcomes inconsistent (some null); well tolerated with very few adverse effects (nausea, diarrhea); can act as an estrogen agonist with sex-dependent effects.
Verified against the source shown. See the research-status page for how review works.
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